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Old 03-20-2006, 04:32 PM   #1
Jonathon Edward
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Ran into this while browsing through a database at work:

Manoukian, A. A., et al. Rhabdomyolysis secondary to lovastatin therapy. Clin Chem. 36(12):2145-2147, 1990.

The authors report a case of lovastatin-induced rhabdomyolysis and resulting life-threatening renal failure. The patient's symptoms and the laboratory values referable to rhabdomyolysis resolved after discontinuation of lovastatin. The authors speculate that the rhabdomyolysis was due to mitochondrial damage secondary to inadequate synthesis of coenzyme Q10 and heme A, members of the electron-transport system of the inner mitochondrial membrane. Lovastatin is known to significantly impair the endogenous synthesis of coenzyme Q10.

I know that this is referring to statins specifically, but it makes me wonder whether supplementing with Co-Q10 may act as an insurance policy to prevent rhabdo?
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Old 03-20-2006, 04:55 PM   #2
David Wood
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Moving to Nutrition . . .
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Old 03-20-2006, 05:44 PM   #3
Garrett Smith
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This is the basic story I've heard regarding the pharmaceutical companies' (specifically Merck) knowledge of statins and CoQ10, from http://www.heart-disease-bypass-surg...rticles/66.htm :

"Merck knew that statins deplete CoQ10, and knew that this could contribute to heart disease. In 1990, this drug manufacturer sought and received a patent for Mevacor and other statin drugs formulated with up to 1,000 mg of coenzyme Q10 to prevent or alleviate cardiomyopathy, a serious condition that can cause congestive heart failure. However, Merck has not brought these combination products to market, nor has this drug company educated physicians on the important of supplementing CoQ10 to offset the dangers of these drugs to the heart. Because they hold the patent, other drug companies are prevented from coming out with a statin/CoQ10 product."

It does not take an endocrinologist to know that if one inhibits cholesterol production, they inhibit the production of every single downstream product (including CoQ10).

Why might people be getting rhabdo related to CoQ10? Here's something to think about, from http://www.questhealthlibrary.com/ot...s/coenzyme_q10:

"CoQ10 is made in the body, but production falls off as we get older. CoQ10 is also found in foods (especially meat), but cooking and processing methods tend to destroy it."

The combination of age, nutrition, and medication could very likely paint quite a picture of rhabdo in middle-aged to older clients.

I have personally started taking a small bit of CoQ10 myself (today, actually). I use the New Chapter (New Mark) version, which I make available in my store:
http://www.new-chapter.com/product/popup/chart_coq10.html
http://www.new-chapter.com/research/coq10.html
http://www.new-chapter.com/research/coq10_skin.html



Considering the probiotic source and the antioxidant capacity of the New Chapter CoQ10 to USP CoQ10, I figure one capsule a day is plenty for someone like me (healthy, eats some raw meat and organs, and isn't & won't ever be on a statin).
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Old 03-21-2006, 04:26 AM   #4
David Wood
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The URLs at the bottom of Garrett's message got messed up; here they are as "live" links.

http://www.new-chapter.com/product/p...art_coq10.html
http://www.new-chapter.com/research/coq10.html
http://www.new-chapter.com/research/coq10_skin.html
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Old 03-21-2006, 08:51 AM   #5
Garrett Smith
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I wanted to clarify that the links posted for the CoQ10 are not direct links to my store (upon looking at my original post, they do look like I'm trying to direct traffic to my site), they are to the manufacturer's website information re: their CoQ10 product.

I would not, nor do I plan to do that on this board.
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Old 03-22-2006, 09:35 PM   #6
Greg Kemp
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DR. G,
I am taking 20mg of Lipitor a day. It sounds like I should be supplementing with Co 10 but how much? Is there any thing else I should be taking with the use of a Statins? Thanks for the help.
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Old 03-23-2006, 11:23 AM   #7
Garrett Smith
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Greg,
I hesitate to prescribe amounts over the board. I have heard other physicians recommend 100-200mg of USP CoQ10 a day for those on statins. If one looks at the comparison link between USP and New Chapter's CoQ10 products that I posted, you'll see that a different amount could be used with the New Chapter product (I use one capsule a day, I'm not on a statin).

If I were in your situation, I would be on CoQ10 and CLO at the minimum. I would also be scrutinizing my diet (and my doctor) very carefully to find the reasons and justifications as to why I was put on a statin in the first place.

Raw heart (grass-fed beef or lamb typically) is a great whole-food source of CoQ10...just had to throw that in there.

I had a client who was put on 5mg of Lipitor a day by his cardiologist for its' "anti-inflammatory" effects! BTW, this cardio also said that CoQ10 was a waste of money...

(Message edited by guerilastrength on March 23, 2006)
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Old 03-23-2006, 12:18 PM   #8
Greg Kemp
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choloesterol was 295

I do only eat grass fed beef now. Have lost 17 lbs and take Fish Oil everyday.

Thank You
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Old 03-23-2006, 09:40 PM   #9
Tim Weaver
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Interesting. I am on 20mg/day Lipitor as well (since 1999)....high cholestorol / MI / CABG. I trake CoQ10 (when I remember!).

I don't know why any cardiologist would take someone off of their statin, etc....I mean, if hte patient did better, then they'd stop coming, etc. Additionally, they are trained that these are the Ways of Things.

Lipitor DOES lower cholesterol. I was 250+. 10mg brought me to about 180-ish. I've got to get re-tested soon.
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Old 03-24-2006, 12:03 PM   #10
Steven C. Herndon
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Dr. G,
I am taking, among other things, 1800 mg of red yeast rice Q-day, which I understand to be a "ntural" statin, and 100 mg of Q-10. Should I stop the red yeast rice, or is it ok with the Q-10?
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