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Old 09-19-2008, 03:40 AM   #21
Camille Lore
 
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Re: Cholesterol and hypercholestrolemia

Frank- I actually found the numbers from two yrs ago:
Triglycerides-167
Cholesterol total-231
hdl-51
ldl-147
ratio- 4.5
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Old 09-19-2008, 10:05 AM   #22
Frank E Morel
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Re: Cholesterol and hypercholestrolemia

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Originally Posted by Camille Lore View Post
Frank- I actually found the numbers from two yrs ago:
Triglycerides-167
Cholesterol total-231
hdl-51
ldl-147
ratio- 4.5
camille, these weren't that bad. I bet if you went and got new blood work that they would be markedly better, Since you have cleaned up your diet and have started an exercise program. Which would be the first step told to you by any MD.

If you do the bloodwork done, post them to this thread so the changes can be seen.
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Old 09-19-2008, 10:10 AM   #23
Camille Lore
 
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Re: Cholesterol and hypercholestrolemia

I will make an appt to get them rechecked and then post. I'm curious, myself.
Thanks.
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Old 09-21-2008, 06:23 PM   #24
Dave Gibbs
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Re: Cholesterol and hypercholestrolemia

ok, checked what it said on the bottle of fish oil capsules.

each 1000mg capsule contains - 300mg omega 3 triglycerites, 180mg EPA, 120mg DHA.

Is this good or bad?

thanks my friends
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Old 09-21-2008, 07:27 PM   #25
Frank E Morel
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Re: Cholesterol and hypercholestrolemia

Its inferior... actually its the run of the mill fish oil.
each cap is a 1000 mg of fish oil, not omegas
so that is 300 mg of omega 3 .. with taking 10 cap per day.. your get the necessary level of omeg 3 but with 10 000 mg of oil.

you can do alot better ..
try to find epa of MIN 400 dha 200 mg in a 1000 but then you only need to take only 4 caps per day to hit that 2000 mg omega 3 dosing point. There are sports related studies that athletes needed 1 g of omegas 3 to stem off imflammatory issues.
There are high concentrate fish oils around..
Not sure of ozzie brands but carlsons is good nordic naturals are very good at 1280 mg of omega 3 per caps.
BETTER bang for dollar is the syrup...I have seen 2600 mg in tsp of oil .. 5mls. and it last alot longer than swallowing the caps on a monthly basis.

005-08-01
JNut - Exercise and nutrition supplements, e.g. fish oil, recommended as first line of defense for lowering cholesterol
Varady K, Jones P. Combination Diet and Exercise Interventions for the Treatment of Dyslipidemia: an Effective Preliminary Strategy to Lower Cholesterol Levels? J. Nutr, 2005; 135:1829-1835.
At present, dyslipidemia is most commonly treated with drug therapy. However, because safety concerns regarding the use of pharmaceutical agents have arisen, a need for alternative nonpharmacological therapies has become increasingly apparent.
The National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III) recommends lifestyle therapies, which include a combination of diet and exercise modifications, in place of drug treatment for patients who fall into an intermediate range of coronary heart disease (CHD) risk.
This review examined the cholesterol lowering efficacy of the following 2 NCEP-recommended combination therapies: 1) low saturated fat diets combined with exercise, and 2) nutritional supplementation, i.e., fish oil, oat bran, or plant sterol supplementation, combined with exercise, in the treatment of dyslipidemia.
Combination therapies are particularly advantageous because diet and exercise elicit complementary effects on lipid profiles. More specifically, diet therapies, with some exceptions, lower total (TC) and LDL cholesterol (LDL-C) concentrations, whereas exercise interventions increase HDL cholesterol (HDL-C) while decreasing triglyceride (TG) levels.
With respect to specific interventions, low saturated fat diets combined with exercise lowered TC, LDL-C, and TG concentrations by 7-18, 7-15, and 4-18%, respectively, while increasing HDL-C levels by 5-14%.

Alternatively, nutritional supplements combined with exercise, decreased TC, LDL-C, and TG concentrations by 8-26, 8-30, and 12-39%, respectively, while increasing HDL-C levels by 2-8%.

These findings suggest that combination lifestyle therapies are an efficacious, preliminary means of improving cholesterol levels in those diagnosed with dyslipidemia, and should be implemented in place of drug therapy when cholesterol levels fall just above the normal range.
Source: Journal of Nutrition


Heart - Fish oil and statin meds in CHD
Durrington P, Bhatnagar D, et al. An omega-3 polyunsaturated fatty acid concentrate administered for one year decreased triglycerides in simvastatin treated patients with coronary heart disease. Heart 2001; 85(5):544-548.
BACKGROUND: Omega-3 fatty acids, such as those present in fish oil, have been reported to prolong life in myocardial infarction survivors. These fatty acids can decrease serum triglyceride concentrations, but so far the doses used in trials examining their effects on coronary end points have had only minimal triglyceride lowering effects.
OBJECTIVE: To examine the triglyceride lowering effectiveness, safety, and tolerability of Omacor, a concentrate of omega-3, long chain, polyunsaturated fatty acids from fish oil (84% of the total as opposed to an average of 35% in fish oil) over one year in patients with established coronary heart disease (CHD) and persisting hypertriglyceridaemia, despite receiving simvastatin in doses similar to those employed in the Scandinavian simvastatin survival study.
SUBJECTS AND METHODS: 59 patients with CHD, receiving simvastatin 10-40 mg daily with serum triglycerides > 2.3 mmol/l, were randomised to receive Omacor 2 g twice a day or placebo for 24 weeks in a double blind trial. Forty six patients accepted the offer of active treatment for a further 24 weeks in an open phase of the trial. RESULTS: There was a sustained significant decrease in serum triglycerides by 20-30% (p < 0.005) and in very low density lipoprotein (VLDL) cholesterol by 30-40% (p < 0.005) in patients receiving active Omacor at three, six, and 12 months compared either to baseline or placebo. Omacor did not have any deleterious effect on low density or high density lipoprotein cholesterol or on biochemical and haematological safety tests. There was no adverse effect on glycaemic control in patients with diabetes, who showed a decrease in serum triglyceride, which was at least as great as in non-diabetic patients. One patient receiving placebo died of acute myocardial infarction. Three patients withdrew from the trial (two on placebo and one on active treatment). Omacor was generally well tolerated.
CONCLUSION: Omacor was found to be a safe and effective means of lowering serum triglycerides over one year in patients with CHD and combined hyperlipidaemia, whose triglycerides remained elevated despite simvastatin treatment.


2005-03-01
AJCN - Omega-3s and dietary counseling improve endothelial markers in hyperlipidemic men
Hjerkinn EM, Seljeflot I, Ellingsen I, et al. Influence of long-term intervention with dietary counseling, long-chain n-3 fatty acid supplements, or both on circulating markers of endothelial activation in men with lo

Background: Dietary factors and very-long-chain n-3 polyunsaturated fatty acids (n-3 PUFAs) may influence the atherothrombotic process. Elevated concentrations of circulating cell adhesion molecules, thrombomodulin (TM), von Willebrand factor (vWF), and tissue-type plasminogen activator antigen (tPAag) are related to atherothrombotic cardiovascular disease.
Objective: The randomized Diet and Omega-3 Intervention Trial (DOIT) targeted a comparison of the effect of 3-y dietary counseling, n-3 PUFA supplementation (2.4 g/d), or both on circulating markers of endothelial activation.
Design: The study included 563 elderly men with long-standing hyperlipidemia. The men were randomly assigned by factorial design into 4 groups: control (no dietary counseling and placebo capsules), dietary counseling (and placebo capsules), n-3 PUFA supplementation (no dietary counseling), and dietary counseling and n-3 PUFA supplementation.
Results: Serum concentrations of fatty acids reflected good compliance. Dietary counseling was followed by significantly reduced concentrations of soluble intercellular adhesion molecule 1 (sICAM-1; P < 0.001), sTM (P = 0.004), and tPAag (P < 0.001) than in subjects without dietary counseling. After n-3 PUFA supplementation, significantly reduced concentrations of sICAM-1 (P < 0.001) and sTM (P = 0.006) were observed when compared with subjects receiving placebo capsules. An increase in tPAag was not significantly different from that observed in subjects receiving placebo capsules. For sICAM-1, a significant effect was observed for both interventions combined.
Conclusions: Each intervention (dietary counseling or n-3 PUFA supplements) reduced sTM and sICAM-1 concentrations, indicating decreased endothelial activation. The tPAag increase in the groups not receiving dietary counseling (pooled), which indicates progression of atherosclerosis, was significantly counteracted by dietary counseling.
Source: American Journal of Clinical Nutrition

2007-12-20
AJCN - EPA and DHA on a daily basis enriches blood lipids
Harris W, Pottala J, Sands S, et al. Comparison of the effects of fish and fish-oil capsules on the n3 fatty acid content of blood cells and plasma phospholipids. American Journal of Clinical Nutrition, 2007;86(6):1621-1625.
Background: n3 Fatty acids (FAs) have been shown to be beneficial for cardiovascular health. Whether n3 FAs from oily fish consumed weekly or from fish-oil capsules taken daily are equally bioavailable is not clear.
Objective: The purpose of this study was to compare the rate and extent of enrichment of blood cell membranes [ie, red blood cells (RBCs)] and plasma phospholipids with n3 FAs from these 2 sources.
Design: Healthy premenopausal female volunteers were randomly assigned to consume a daily average of 485 mg eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids either from 2 servings of oily fish (ie, salmon and albacore tuna) per week or from 12 capsules/d.
Results: After 16 wk, EPA+DHA in RBCs in the fish group (n = 11) increased from 4.0 0.6% of total FAs to 6.2 1.4%, whereas it rose from 4.3 1.0% to 6.2 1.4% in the capsule group (P < 0.0001 for both; NS for group effect). Similar results were observed in plasma phospholipids. EPA+DHA stabilized in the latter after 4 wk but continued to rise through week 16 in RBCs. EPA in RBCs increased significantly (P = 0.01) more rapidly in the fish group than in the capsule group during the first 4 wk, but rates did not differ significantly between groups thereafter. Total FA variances were less in RBCs than in plasma phospholipids (P = 0.04).
Conclusion: These findings suggest that the consumption of equal amounts of EPA and DHA from oily fish on a weekly basis or from fish-oil capsules on a daily basis is equally effective at enriching blood lipids with n3 FAs.
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Old 09-21-2008, 07:36 PM   #26
Brandon Oto
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Re: Cholesterol and hypercholestrolemia

Just for some reference...

Diet is far from anal but generally clean, certainly not Zoned, lots of fat, lots of fish oil, exercise is varied but hasn't been CF (or anything as intense) in quite a while, age is 21, weight is 180, BF unremarkable for a CFer (maybe high teens), BP and HR pretty average.

Just got my blood done for the first time in forever, coming back as:

Total cholesterol: 188
LDL: 108
HDL: 71
Triglycerides: 47
VLDL: 9

Probably a nice neighborhood to shoot for.
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Old 09-24-2008, 07:05 PM   #27
Robert Pierce
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Re: Cholesterol and hypercholestrolemia

Not sure if Frank mentioned GISSI. The GISSI trial done in 1999 was the landmark trial for 0-3 FA. More recently, GISSI-HF was released, showing a benefit of O-3 FA in patients with heart failure (whereas there was no benefit from Crestor, a statin).

Looks like a decent wfs link: http://www.ochsnerjournal.org/perlse...24-5012(2008)8[49%c]2.0.CO%3B2&ct=1

Edited to say, the link is apparently broken. Try googling "artham fish oil site: www.ochsnerjournal.org"
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Last edited by Robert Pierce : 09-24-2008 at 07:11 PM. Reason: broken link
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Old 09-25-2008, 11:44 PM   #28
Frank E Morel
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Re: Cholesterol and hypercholestrolemia

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Originally Posted by Robert Pierce View Post
Not sure if Frank mentioned GISSI. The GISSI trial done in 1999 was the landmark trial for 0-3 FA. More recently, GISSI-HF was released, showing a benefit of O-3 FA in patients with heart failure (whereas there was no benefit from Crestor, a statin). "
ouch... I bet that was a kick in the pants for the crestor people!
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