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Old 12-22-2007, 03:07 PM   #1
Rich Krauss
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elevated liver function test

recently had blood test which showed elevated liver function(ALT,AST). Only positive history that I have that might cause this was hard exercise, and few glasses of wine day before blood test. I also take carlson's fish oil 2 Tbsp/day. Anyone hear of a similar experience or know of an association between fish oil and elevated liver function tests?
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Old 12-25-2007, 10:00 AM   #2
Craig Van De Walker
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Re: elevated liver function test

Things off the top of my head that may be associated with elevated liver enzymes.

Are you on statins?

Are you taking real high dose niacin like thousands of mg per day?

have you been tested for hepatitis? Lots of people walk around with Hep-C and don't know it (it is endemic in some Asian countries), you could also have a case of food borne hep-A. If you are in healthcare hep-B is a concern. Also alcoholic hepatitis.

blow to the liver?

are you obese?

How elevated were the numbers just out of normal range or like 50 times normal? Maybe your normal baseline is just slightly out of range.

I would suggest you ask pointed questions to your Dr. Get another test done labs make mistakes. If you do have more concerns I would insist on going to a liver specialist (hepatologist)

I would definitely follow up as the liver is one of those "fairly important" organs.

Last edited by Craig Van De Walker : 12-25-2007 at 10:02 AM.
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Old 02-25-2008, 12:15 PM   #3
Michael Brewer
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Re: elevated liver function test

I just got my blood work back from my doctor. Looks like my liver function levels are elevated as well. I will be going to the doctor next week for a follow-up exam and blood work.

The two common factors that would apply in my case are regular strenouous exercise and regular headaches treated by tylenol. No tylenol for the next week, but I will still be CrossFitting.
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Old 02-25-2008, 07:52 PM   #4
Frank E Morel
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Re: elevated liver function test

There are several points that need to be explained.
liver function test LFT or hepatic panel vary from day to day to begin with. But are influenced greatly but alot of factors.

Drinks prior to your blood draw.... yes this can in impact your test results, as much as week out. Depends on the volume but a single drink the night before.. as is yes.

Use of otc drugs.. yes.. these drugs are hard on the liver especially if you exceed the 4 grams per day dosing, which usually happens on the unsuspecting when you have a cold and are using various cold flu otc drugs. As lot of them have tylenol in the mix.. so having aches and pains.. you take tylenol am ... for the stuff congestion you take mucenex ..( contains tylenol) , fever.. tylenol get to sleep nyquil..(tylenol and alcohol) easy to layer up these drugs yet .. you skirt the high dosing mark and do that for a couple of days.. and you do end up with high lfts.


Are you on statins?
very hard on the liver...
drugs are removed from the body two ways... liver and kidneys. statins have along list of problems.


Are you taking real high dose niacin like thousands of mg per day?
never really proven to be hard .. but its assumed. yes you would have take 2-5 grams per day.. but again.. its assumed. Besides... this has never really proven to lower cholestrol
saying that you have not revealed that you have a hyperlipid problem.

have you been tested for hepatitis? Lots of people walk around with Hep-C and don't know it (it is endemic in some Asian countries)
Wrong.

, you could also have a case of food borne hep-A.
Wrong
If you are in healthcare hep-B is a concern.
Wrong

Hep A is hepatitis that stems from food contaminated with feces.. ie the cook doesn't bother to wash their hands.. you are ill and turn jaundice ( the old school name for hepatitis where people went yellow-orange)
it has an incubation period and the symptoms turn to signs and you are orange for a time period. YOU WOULD KNOW THAT YOU HAVE IT.
its over in 6 weeks

ligher note... you can be vaccinated for hep a and i believe its good for a year. Travelling to a third world or second word country.. this is worth its weight in gold.

Hep B ... THIS IS A VERY COMMON STRAIN OF hep. But not LIMITED TO HEALTHCARE WORKERS..
the transmission vector (meaning the way its passed around ) is by saliva, body fluids and blood. Its a long living virus meaning.. on the floor a drop of this virus would be able to live without a host (something to live off) is one day. HIV is down to a few hours.

saliva.. yes you can catch this from kissing.. or sharing infected glassware or kitchen utensils... Hep b is common in cultures that share food, ie middle east africa and asia.
Hookers dont french kiss for a reason.

Body fluid... urine.. seman, and vaginal secretions are the routes to infection.

Blood ... absolutely... hep b common with persons who are using needles for drug usage. or contaminated blood transfusions.( all blood products are screened for this)

not only health care works have possible exposure, so do police, fire, soldiers, public utilities workers.. the list is long.

hep b vaccine is possible and recommended.

Hep C/d/e ... common vector is blood and stems from IV drug usage
no vaccine avail

Also alcoholic hepatitis.
old school name for cirrhosis...couple that with beer bottle glasses and the village hooker looks good.


blow to the liver?
yes.. most common everyday occurance... driving along... you suddenly hit your brakes... the seat belt tightens up and squeezes you.
Contact sports common results.


are you obese?
associated with a fatty liver... not being fat. two different things..
you can be fat and have normal lft.

How elevated were the numbers just out of normal range or like 50 times normal? Maybe your normal baseline is just slightly out of range.
wrong... if your baseline are high... its because you have something going on and its now chronic.


heavy exercise...
not necessarily true...
if this was.. people who do alot of manual labour of a heavy nature like masons, or steel workers, warehousemen would be walking around with high lft.. and they are not. Perhaps prior to your next blood draw.. dont work out for a couple of days. After all, you want to eliminate the chance of missing something most sinister like a liver tumor... wouldnt you?

I would suggest you ask pointed questions to your Dr. Get another test done labs make mistakes.
yes... true, but more importantly... no drinking prior to the test, no otc prior to the test. Again.. no crossfit.

perhaps you had a bout of mononucleosis, ebv or cmv all would pop your results.. these can be near noticed virus or perhaps you threw a pancreatic stone, Multiple reasons.. But when you hear horse hooves.. don't think zebras.

If you do have more concerns I would insist on going to a liver specialist (hepatologist)
Not necessary... most health insurance plans do not take such referrals to sub specialities. There has to be a problem at hand. if the second test came back high.. then there is still a couple of simple tests prior to see the hepatologists.. they are few and not common in alot of medical centers. Gastro doctors usually have some exposures but refer onwards.

See your regular doctor and problem solve together.



I would definitely follow up as the liver is one of those "fairly important" organs.
actually.. its a very important organ.. no liver... your dead in weeks.


But to answer your original question.. fish oil affect lft... unlikely.

Last edited by Frank E Morel : 02-25-2008 at 07:56 PM.
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Old 05-07-2008, 05:41 PM   #5
Michael Brewer
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Re: elevated liver function test

Following up: I had a second liver test a week after the first. I abstained from use of tylenol, as I use(d) it quite often for regular headaches. The second liver test came back normal.
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Old 05-07-2008, 07:19 PM   #6
Liana Mark
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Re: elevated liver function test

Coming from a pharmacy student who gets these blood chemistries drilled into my brain on a daily basis, the most probable cause of your elevated LFTs is strenuous exercise. In addition to the liver, the muscles also have some transaminases in them, so when they get broken down, they are released into the blood & they show up as elevated AST.

It's unlikely that moderate drinking would cause an increase in LFTs, as the elevation is a result of damaged hepatocytes. If you were an alcoholic with liver cirrhosis, then it would be a different story.

Either way, it's definitely a good idea that you get tested again just to be on the safe side!
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Old 05-07-2008, 08:18 PM   #7
Frank E Morel
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Re: elevated liver function test

ahem... this is an old thread...


and as a pharma student.... try looking up the side effects of APAP and toxicity effects.

that will be your answer... which is what he admitted to in the last post...
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Old 05-08-2008, 07:10 AM   #8
Liana Mark
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Re: elevated liver function test

the apap tox was a different person ..

and i didnt realize what an old post it was until i already sent an answer .. sorry
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Old 05-08-2008, 10:56 PM   #9
Frank E Morel
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Re: elevated liver function test

liana...here is what he said.

Following up: I had a second liver test a week after the first. I abstained from use of tylenol, as I use(d) it quite often for regular headaches. The second liver test came back normal.

4 grams plus of apap is toxic ... that means HEPATIC TOXIC.
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